BIOINFORMATICS TOOLS FOR NGS-BASED IDENTIFICATION OF SINGLE NUCLEOTIDE VARIANTS AND LARGE-SCALE REARRANGEMENTS IN MITOCHONDRIAL DNA

Bioinformatics Tools for NGS-Based Identification of Single Nucleotide Variants and Large-Scale Rearrangements in Mitochondrial DNA

The unique features of mitochondrial DNA (mtDNA), including its circular and multicopy nature, the possible coexistence of wild-type and mutant molecules (i.e., heteroplasmy) and the presence of nuclear mitochondrial amina muaddi scarpe trasparenti DNA segments (NUMTs), make the diagnosis of mtDNA diseases particularly challenging.The extensive dep

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Cardiac-specific overexpression of perilipin 5 provokes severe cardiac steatosis via the formation of a lipolytic barrier[S]

here Cardiac triacylglycerol (TG) catabolism critically depends on the TG hydrolytic activity of adipose triglyceride lipase (ATGL).Perilipin 5 (Plin5) is expressed in cardiac muscle (CM) and has been shown to interact with ATGL and its coactivator comparative gene identification-58 (CGI-58).Furthermore, ectopic Plin5 expression increases cellular

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Optimization of the virtual mouse HeadMouse to foster its classroom use by children with physical disabilities

This paper presents the optimization of a virtual mouse called HeadMouse in order to foster its classroom use by children with physical disabilities.HeadMouse is an absolute vegetable glycerin for sale virtual mouse that converts head movements in cursor displacement and facial gestures in click actions.The virtual mouse combines different image pr

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Arkaim Textile

The paper highlights the results of research of textile impressions on the read more inside of fragments of ceramic vessels from the collection of fortified settlement Arkaim in the Southern Trans-Urals.The technological characteristics of textiles, reconstructed on the basis of the analysis of impressions-positives from imprints, are given.All tex

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